Granulomatosis with polyangiitis is a mouthful of a medical term and can be a challenge to pronounce, spell and remember. Some synonyms or alternative names for this condition include Wegener's granulomatosis, GPA, and ANCA-associated vasculitis. Another synonym is a necrotizing granulomatous vasculitis, which describes how the immune system's reaction to an unknown trigger leads to inflammation and destruction of the blood vessels. These alternative names can be helpful shortcuts when discussing this disease with medical professionals or others affected by this chronic condition. Despite the various synonyms, granulomatosis with polyangiitis remains a rare but serious autoimmune disease that often requires ongoing treatment and management.