Grim humors, also known as melancholy or black bile, can be a difficult state to shake off. However, there are many synonyms for this term that describe a similar feeling of sadness or pessimism. For example, despondency, hopelessness, and despair all convey a sense of deep emotional pain. Ennui, melancholia, and moroseness suggest a sense of listlessness or emptiness. Other terms such as dejection, glumness, and melancholy indicate a state of sadness or gloominess that may be difficult to overcome. Ultimately, while the words may differ, the underlying feelings they describe are universal and can be a common experience for many people at different times in their lives.