Hallopeaus disease, also known as erythema exsudativum multiforme major (EEMM), is a rare but severe inflammatory skin condition. Characterized by target-shaped skin lesions, blisters, and mucosal involvement, this disorder can cause significant discomfort and complications. While the term "Hallopeaus disease" is commonly used, it is essential to acknowledge its interchangeable synonym, EEMM. This synonym helps to facilitate effective communication between healthcare professionals and ensures accurate diagnosis and treatment. Understanding these synonyms allows medical practitioners and patients to share relevant information and insights, enhancing patient care and collaboration in managing this challenging condition.