The term "harbor mutation" refers to a genetic mutation that occurs in a germ cell, leading to the transmission of the mutation to offspring. Synonyms for harbor mutation include germ-line mutation, heritable mutation, and germline alteration. Such mutations can have a profound effect on an individual's health and often play a role in the development of genetic disorders. Understanding the mechanisms underlying harbor mutations is critical in assessing and mitigating the potential risks associated with genetic disorders. New research around these mutations will play a crucial role in the development of new treatments and therapies to address these genetic diseases.