Having the know-how means having the skills, knowledge, and experience to do something successfully. Antonyms for this term could include words such as ineptitude, cluelessness, incompetence, ignorance or unfamiliarity. These words refer to a lack of understanding or ability in a particular area. For example, someone who is clueless about a particular topic or task may not know where to start or how to achieve the desired outcome. On the other hand, someone who has knowledge and expertise in a particular field may be seen as proficient, skilled, or accomplished. In summary, the opposite of having the know-how would be a lack of knowledge, competence, or expertise in a particular area.