Heat chemotherapy, also known as hyperthermic intraperitoneal chemotherapy (HIPEC), is a treatment for abdominal and pelvic cancers. It involves heating chemotherapy drugs and administering them directly into the abdominal cavity during surgery. This approach allows for a higher concentration of drugs to be delivered to the cancer cells, as well as enhancing their effectiveness through the application of heat. Synonyms for heat chemotherapy include perfusion chemotherapy, intraoperative chemotherapy, and heated intraperitoneal chemotherapy. All of these terms describe the same method of treatment, where chemotherapy is delivered directly to the affected area and enhanced with the use of heat. Heat chemotherapy has shown promising results for treating certain types of abdominal and pelvic cancers and is becoming more widely accepted as a treatment option.