Hereditary CNS demyelinating disease refers to a group of inherited disorders that affect the central nervous system and lead to demyelination. Demyelination is the damage to myelin, the protective coating that surrounds nerve fibers. This disease can affect people of any age, and the signs and symptoms can vary widely depending on the specific type of the disease. Some synonyms for this condition include genetic disorders of the central nervous system causing loss of the myelin sheath, heritable disorders of the nervous system leading to demyelination, and inherited disorders of the central nervous system that cause demyelination. Regardless of the terminology used, these conditions are debilitating and can have a significant impact on the lives of those affected and their families.