Herlitz Disease, also known as junctional epidermolysis bullosa, is a rare and severe genetic skin disorder. It is characterized by the formation of blisters and erosions on the skin, mucous membranes, and internal organs. While the term "Herlitz Disease" specifically refers to this condition, it is important to note that there are other synonyms used within the medical field. These include junctional epidermolysis bullosa Herlitz type, Herlitz junctional epidermolysis bullosa, or simply, Herlitz EB. These synonymous terms are used to describe the same affliction, highlighting the impaired junctions between the layers of skin. Early diagnosis and proper management of Herlitz Disease is crucial to improving the quality of life for those affected by this debilitating condition.