High pairing mutation refers to a genetic mutation that changes the way DNA pairs up during replication. This can result in changes to the amino acid sequence of a protein, which can have significant impacts on an organism's traits. Synonyms for high pairing mutation include high fidelity mutation, which refers to changes in the DNA that are accurately replicated during cell division, and high frequency mutation, which describes mutations that occur more frequently than usual. Another synonym is hypermutation, which refers to an increased rate of genetic mutations. Regardless of the term used, understanding high pairing mutation is critical to understanding genetic variability and its effects on living systems.