High-output heart failure is a condition where the heart is unable to pump enough blood to meet the body's demands despite a normal ejection fraction. There are a few synonymous terms for high-output heart failure such as cardiac cachexia, congestive heart failure, and cardiomyopathy. Cardiac cachexia refers to the wasting of body mass due to the heart's inability to supply necessary nutrients. Congestive heart failure is a condition that leads to fluid accumulation in the body because of the heart's inability to pump enough blood. Cardiomyopathy is the weakening of the heart muscle, which leads to inefficient circulation and ultimately failure to meet the body's needs. Regardless of the name, recognizing and treating high-output heart failure is key to improving outcomes in affected individuals.