The phrase "hit bottle" generally refers to the consumption of alcoholic beverages. Consequently, antonyms for "hit bottle" would be words that imply restraint, sobriety and responsibility. Some possible antonyms include "abstain," "refrain," "control," "moderate," "temperance," "self-mastery," "abstinence," "soberness," "discipline," "moderation" and "restraint." These words imply the opposite of excessive drinking and substance abuse. Practicing moderation and self-control is essential for a healthy and productive life, both physically and mentally. So, next time when you are tempted to indulge in excessive alcohol, remember the antonyms of "hit bottle" and choose a healthier and more responsible lifestyle.