Home on is a phrase that is commonly used to describe someone or something that feels comfortable and familiar with a particular subject or activity. Synonyms for this phrase include words such as proficient, expert, skilled, and adept. These words all convey a sense of mastery and confidence in a given area. Additionally, the phrase "at home with" can also be used to convey the same sense of comfort and familiarity. Other synonyms that convey similar meanings include words such as knowledgeable, experienced, seasoned, and accomplished. These words all suggest that the individual or entity in question is highly skilled and capable in a particular area of expertise or interest.