"Hostilize" is a unique word that denotes the act of making someone or something hostile or unfriendly. In the realm of synonyms, several alternative words can precisely convey a similar meaning. One such synonym for "hostilize" is "antagonize", describing the act of provoking or inciting hostility in someone. Another option is "alienate", which refers to creating a sense of distance or isolation, often leading to antagonistic feelings. "Offend" can also be used, emphasizing actions that cause someone to feel resentment or animosity. Lastly, "estrange" captures the idea of putting a strain on a relationship, leading to an atmosphere of hostility and discord. Overall, these synonyms provide multiple avenues to articulate the act of making someone or something hostile.