Hypermethylation is a common term in epigenetics for the addition of a methyl group to DNA, which can lead to gene silencing or aberrant gene expression. Synonyms for hypermethylated include overmethylated, excessively methylated, abnormally methylated, and heavily methylated. Other terms used in context with hypermethylated DNA are methylated-rich, CpG island methylator phenotype (CIMP), and DNA methylation signature. Hypermethylation is also associated with aging, cancer, and other diseases. In research and medical fields, accurate synonyms for hypermethylation are critical for understanding and exploring the impact of epigenetic modifications on gene regulation and disease states.