Hypermorphic is a term used to describe a gene mutation that results in an altered protein that retains some level of activity. Some synonyms for hypermorphic include enhanced, increased, upregulated, elevated, augmented, amplified, enriched, intensified, potentiated, and strengthened. These terms are often used to describe an increase in gene activity or protein function. Hypermorphic mutations play an important role in development and disease and understanding their impact can aid in drug development and therapeutic intervention. The use of these synonyms can help researchers identify and differentiate between different types of mutations and disease states associated with altered gene activity.