Idiopathic sclerosing mesenteritis is a rare and poorly understood condition that affects the mesentery, a membrane that supports the intestines. There are no known causes or risk factors for this disorder, making it difficult to diagnose and treat. Synonyms for idiopathic sclerosing mesenteritis include mesenteric panniculitis, mesenteric lipodystrophy, and mesenteric fibromatosis. Symptoms of the disease can vary but often include abdominal pain, diarrhea, and weight loss. Treatment options may include medications to alleviate symptoms or surgery to remove the affected tissue. As research on this condition continues, it is hoped that more effective treatment options will become available.