The phrase "in a frazzle" typically refers to a state of extreme exhaustion, stress or disarray. As an alternative, one might use synonyms such as "frazzled" or "weary" to describe the feeling of being completely drained of energy or resources. Other similar terms include "distracted," "discombobulated," "scattered," "frenzied," "disoriented" or "frantic." Depending on the context, one could also use idiomatic expressions such as "at the end of one's rope," "running on fumes," or "at one's wit's end" to convey the same sense of emotional or physical exhaustion.