In the course of is a commonly used phrase that means during the process of doing something or over a period of time. However, there are several synonyms that one can use instead of this phrase. Some of these include 'during', 'while', 'as', 'throughout', 'amidst', 'in the process of', 'in the midst of', 'through the course of', and 'over the course of'. These synonyms can be used interchangeably depending on the context in which the phrase is used. Having several alternatives to common phrases like in the course of helps to add variety to writing and make it more interesting.