When we talk about something that is in operation, we are usually referring to the fact that it is functioning or working as intended. There are a number of different synonyms for this phrase that can be used depending on the context. Some of these synonyms might include things like "is working," "is being used," "is in use," "is in effect," or "is operational." Other possibilities might include "is running," "is active," "is functioning," or "is underway." Ultimately, the choice of synonym will depend on the specific context in which the phrase is being used, and the desired connotations and messaging that are being conveyed.