When someone is not in good spirits or demeanor, we may say "something is off with you." However, there are many other ways to convey this sentiment. For example, you could say that you are sensing a change in their energy or mood. Alternatively, you may observe that they seem distracted or preoccupied. Another way to express this is to say that their behavior is unusual or different than usual. These phrases can be useful in describing the nuances of somebody's emotions and behavior, which can help improve communication and understanding in relationships and social interactions.