Isocoding mutation is defined as a change in DNA sequence that results in the same amino acid being coded for during protein synthesis. Synonyms for this term include synonymous mutation, silent mutation, and synonymous substitution. These mutations occur when a nucleotide substitution only affects the third position in a codon, which is often considered the least important. While these mutations may not have a noticeable effect on the resulting protein, they can still have implications for gene regulation and disease susceptibility. Understanding synonyms for isocoding mutation can aid in the identification and analysis of genetic variations and their potential impact on human health.