Joseph Disease, also known as Machado-Joseph Disease (MJD), is a genetic disorder characterized by progressive nerve damage leading to mobility impairment and muscle wasting. Synonyms for Joseph Disease, used to describe this condition, include Spinocerebellar Ataxia Type 3 (SCA3) and Azorean Disease. These terms are used interchangeably to refer to the same inherited neurodegenerative disorder. Regardless of the synonym used, this debilitating condition affects individuals worldwide, causing coordination difficulties, speech problems, and involuntary eye movements. While there is no cure for Joseph Disease at present, treatment focuses on managing symptoms and improving the quality of life for those affected by this challenging neurological disorder.