Keratoderma Palmoplantar Diffuse, a rare dermatological condition, is characterized by the thickening of the skin on the palms and soles. While it may be a mouthful, there are several synonyms for this condition. One alternative term is "Diffuse Palmoplantar Keratoderma", which describes the same thickening of the skin. Another synonym is "Focal Palmoplantar Keratoderma", which refers to a localized form of this condition. Additionally, this condition can also be referred to as "Diffuse Hyperkeratosis of Palms and Soles". Regardless of the terminology used, it is essential to recognize the symptoms of this condition and seek proper medical attention for appropriate diagnosis and treatment.