One possible synonym for the phrase "kicking in" is "taking effect." This can be used to describe how a medication, treatment, or other substance begins to have an impact on the body or mind. Another alternative might be "starting up," which can be used in reference to a machine or engine that begins to work properly or become operational. A more colloquial synonym might be "getting going," which could apply to an undertaking or activity that begins to pick up momentum or become more intense. Overall, the choice of synonym will depend on the context and intended meaning of the original phrase.