The term knobber has several synonyms that can be used to describe a person who is annoying or bothersome. For instance, one might refer to such an individual as a pest, irritant, nuisance, or vexation. Alternatively, one might call them a gadfly, troublemaker, or agitator. These terms all refer to someone who is difficult to deal with and can cause frustration or irritation. Additionally, if someone is being overly critical or picky, they might be referred to as a nitpicker, fault-finder, or carper. Overall, there are many synonyms for knobber that can be used to describe someone who is difficult to please or problematic.