Lambert-Eaton Myasthenic Syndrome (LEMS) is a rare neurological disorder that affects the connection between nerve and muscle cells. This results in muscle weakness and fatigue, especially in the limbs. Some synonyms for LEMS include Eaton-Lambert Syndrome, Myasthenic Syndrome, Autonomic Neuropathy, and Paraneoplastic Syndrome. LEMS can be associated with autoimmune disorders, certain types of cancer, and exposure to certain toxins. Common symptoms include muscle fatigue, difficulty walking, difficulty with fine motor skills, and dry mouth. Treatment for LEMS usually includes medications, physical therapy, and management of any underlying conditions. With proper care, individuals with LEMS can manage their symptoms and lead a fulfilling life.