While "laughs up" is a colloquial phrase that's not frequently used, there are several synonyms for it that can be employed instead. One of the most common is "laugh heartily," which conveys the same idea of laughing joyfully and uninhibitedly. Another option is "cracks up," which can have a slightly more humorous connotation than "laughs up." Other possibilities include "guffaws," "chuckles," and "roars with laughter." Ultimately, the best synonym for "laughs up" will depend on the context of the sentence and the intended tone of the writing or speech.