"Lead with" is a commonly used phrase that means to take charge or start off with a particular action or statement. However, there are many other words that can be used to express the same concept. For example, one can "initiate" a plan, "kick-off" a project, "launch" an event, "begin" a discussion, "commence" a partnership, or "pioneer" a new venture. Using synonyms for "lead with" can help to add variety and nuance to your language, and demonstrate a broader vocabulary. Additionally, choosing the right synonym can help to convey a particular tone or attitude, such as boldness, confidence, or urgency.