Leprose is an adjective that is often used to describe something that is scaly or scabrous in nature. The antonyms of leprose generally refer to characteristics that are smooth, soft or silky. These antonyms include terms such as smooth, polished, lustrous, sleek, slippery, glossy, and velvety. The opposite of leprose is zooth, which means being smooth, soft and furry. Other antonyms of leprose include terms such as refined, elegant, chic, sophisticated, and smart. These terms are more appropriate for describing fashion styles, decor, and lifestyle choices. Overall, the antonyms of leprose generally refer to a sense of elegance and refinement, which is the opposite of rough and scabrous textures.