The phrase "let go with" implies releasing something or allowing it to happen freely. Synonyms for this phrase include "unleash," "set free," "release," "liberate," and "loosen the reins." These words all emphasize the act of allowing something to happen without constraint. Other synonyms include "give up control," "discard," "surrender," "abdicate," and "relinquish." These words convey a sense of giving up something or letting it go for good. Additionally, "allow," "permit," "enable," and "facilitate" can also be used as synonyms for "let go with," as they all suggest giving something the opportunity to happen or exist.