Lissencephaly is a rare neurological disorder in which the brain lacks the normal folds and grooves typical of a healthy brain. It is also known as "smooth brain syndrome" or "agyria-pachygyria complex." Other possible synonyms for lissencephaly include "simplified brain," "gyrification disorder," "neuronal migration disorder," "brain malformation," and "cortical dysplasia." This condition can cause significant developmental delays, seizures, difficulty swallowing, and other serious medical complications. While there is no known cure for lissencephaly, treatment may involve managing symptoms and providing supportive care. Early detection and intervention can help improve outcomes for individuals with this condition.