Lose wits is an idiomatic expression that refers to losing one's sanity or becoming mentally unstable. There are several synonyms for this phrase that are commonly used. One such synonym is the phrase "lose one's mind," which means the same as "lose wits." Another synonym is "go crazy," which implies a sudden and extreme loss of mental stability. "Lose one's marbles" is also a popular synonym for "lose wits," which refers to becoming irrational or behaving erratically. "Flip one's lid" is another expression that has the same connotations as "lose wits," indicating a loss of control or a breakdown of mental faculties. Ultimately, these phrases all describe a state of mind characterized by irrationality and disorientation.