Loss of soul is a phrase that describes a lack of purpose, meaning, or passion in life. There are many synonyms for this concept, each with its own nuances and connotations. For example, ennui refers to a feeling of boredom or listlessness, while malaise suggests a more general sense of unease or discomfort. Apathy describes a lack of interest or enthusiasm, while desolation implies a sense of abandonment or isolation. Other synonyms for loss of soul include weariness, disenchanted, disillusioned, and empty. Ultimately, all of these words point towards the same underlying feeling; a sense of disconnection from the world and a profound longing for something more.