The phrase "lost one's wits" is commonly used to describe someone who has become confused, bewildered or mentally unsettled. There are plenty of synonyms for this phrase that can be used interchangeably. Some of these synonyms include "lost one's marbles," "gone crazy," "insane," "mentally deranged," "out of one's mind," "crazy as a loon," "mad as a hatter," and "off one's rocker." Each of these phrases describes a state of mind where a person has lost their ability to think or act normally. Whether it's due to stress, illness, or trauma, these phrases help convey the idea of someone who has lost control of their mind and cannot function normally.