The antonyms for the phrase "make handsome" can include "deface," "ruin," "disfigure," "disfigurement," "mutilate," "distort," "blemish," "scar," "discolor," and "mar." These terms are used to describe the opposite of making someone or something look attractive or appealing. When an individual or object is defaced, it means that its original beauty or appeal has been spoiled, often through destructive or unsightly means. Similarly, words like disfigurement or mutilation imply that someone has been physically altered in a way that detracts from their appearance. Overall, there are many antonyms for the phrase "make handsome," all of which describe negative or unpleasant changes to something previously considered attractive.