When it comes to synonyms for the phrase "make impossible," there are many options available. Some of the most common synonyms include "prevent," "hinder," "bar," "obstruct," "block," and "thwart." Other possible alternatives to this phrase include "render impracticable," "impede," "neutralize," "nullify," "undermine," "foil," and "deter." Depending on the context in which the phrase is used, different synonyms may be more appropriate than others. Regardless of which synonym is chosen, however, all convey the same general idea of preventing something from occurring or being achieved.