Antonyms for the phrase "makes a go of it" include "give up," "fail," "abandon," "throw in the towel," and "surrender." These words denote a lack of persistence, determination, and effort in achieving an objective or reaching a goal. They imply a negative connotation, indicating that the individual did not make an honest attempt to succeed.
In contrast, synonyms for "makes a go of it" include "persevere," "persist," "endure," "strive," and "continue to try." These words suggest an attitude of resilience, patience, and optimism in the face of challenges and obstacles. They are positive affirmations that an individual is actively working towards their goal, and not willing to easily give up.