Mammalian Artificial Chromosome (MAC) is a term used to refer to the engineered chromosomes used in gene therapy. These chromosomes are specially designed to mimic natural chromosomes found in mammals. MACs are used to introduce therapeutic genes into mammalian cells, which can provide treatment for genetic disorders. Some synonyms for MAC include Synthetic Chromosome, Artificial Chromosome, and Engineered Chromosome. The process of creating MACs involves DNA synthesis and the use of CRISPR/Cas9 technology. These advanced tools help scientists to engineer new chromosomes that can deliver genes to specific cells in the body. While MACs are still in the experimental stage, researchers hope that one day they will provide a viable treatment option for a range of genetic diseases.