Manduca quinquemaculata, commonly known as the tomato hornworm, is a notorious pest that feeds on tomato plants. This green caterpillar has synonyms that include the tobacco hornworm, sphinx moth, and Carolina sphinx moth. Although it is a destructive insect, it serves as a valuable food source for birds and other predators. Manduca quinquemaculata is also considered a valuable research subject due to its innate immune system that allows it to thrive in harsh environments. Its numerous synonyms reflect its widespread distribution throughout North and South America, as well as its significant impact on agriculture. Despite its destructive tendencies, this species remains an important part of the ecosystem.