"Mano a mano" is a Spanish phrase that means a direct confrontation between two parties, usually in a one-on-one setting. There are several synonyms for this phrase that can be used to convey the same meaning in different contexts. Some of the most common synonyms for "mano a mano" are face-to-face, head-to-head, one-on-one, mono e mono, eyeball-to-eyeball, toe-to-toe, nose-to-nose, and in close quarters. These expressions can be used to describe situations where two individuals are engaged in intense competition, negotiations, or any other activity that requires them to be in close proximity. Choosing the right synonym depends on the context and the tone you want to convey.