Meddling with something refers to an act of interfering with it. It can be intentional or unintentional but may cause harm to the affected. There are several synonyms that capture the same meaning as meddle with. These include tamper with, fiddle with, interfere with, mediate, manipulate, tinker with, and intrude on. Each of these synonyms is commonly used to mean to alter something or change its intended state, mostly in a negative way. For instance, tampering with evidence in a court of law is a criminal offense, and meddling with someone's relationship may result in broken hearts. Therefore, it is crucial to think twice before meddling with anything.