Meleda disease, also known as keratoderma palmoplantaris, is a rare inherited skin disorder that affects the palms of the hands and soles of the feet. This condition causes thick, dry, and scaly skin, leading to various discomforts. Although Meleda disease is primarily recognized by this name, it might be useful to know some alternate terms for it. Synonyms for Meleda disease include Mal del Meleda, Meleda disease of the skin, Unna-Thost keratoderma, palmoplantar keratoderma type 4, and keratoderma hereditarium palmoplantaris (KPP). Familiarity with these synonyms can assist in medical discussions, research, and understanding the different aspects of this rare skin disorder.