Minimal change disease, also known as lipoid nephrosis, is a kidney disease that causes abnormalities in the glomeruli in the kidneys. The condition is known for causing minimal changes under a microscope, which is why it is called minimal change disease. Other synonyms for this condition include idiopathic nephrotic syndrome, steroid-sensitive nephrotic syndrome, and nephrosis. While the exact cause of this disease is unknown, it is believed to be linked to an autoimmune response in the body. Symptoms of minimal change disease include swelling, protein in urine, and fatigue. Treatment typically involves the use of corticosteroids and immunosuppressive drugs.