Missouri mule is a term used to describe hybrid mules that were bred in the state of Missouri. However, this term has several synonyms, including Missouri hybrids, Missouri mulefoot, Missouri trotting mule, Missouri bred mules, and Missouri mule-ear. These mules were popular in the 19th century and were widely used in agriculture and transportation. The Missouri hybrids were known for their stamina, strength, and endurance, which made them popular among farmers and teamsters. Despite their popularity, Missouri mules faced several challenges, including the emergence of automobiles and tractors, which led to a decrease in the demand for mules. However, the term Missouri mule remains relevant to this day and is still used by many people to describe mules bred in Missouri.