The antonyms for the phrase "mix it with" can include words like separate, divide, segregate, isolate, or extract. These words suggest a separation or disconnect between two or more things. When you separate or isolate something from something else, you are preventing them from mixing. Dividing something implies a split that separates things completely. Conversely, however, combining items can also mean to merge or blend, thus forming a new entity. Choosing the right antonym depends on the context in which it's used. Therefore, it's crucial to understand the overall meaning of the sentence to identify an appropriate antonym for "mixing.