The antonyms for the word "more itty-bitty" can be found by considering the opposite attributes of smallness. Words like large, big, enormous, colossal, and gargantuan can be used as antonyms for "more itty-bitty." Conversely, adjectives such as significant, important, major, crucial, and vital represent semantic opposites of "more itty-bitty" in terms of significance and relevance. The antonyms for "more itty-bitty" also depend on the context in which the word is used. For example, if referring to a small object, the antonyms might be substantial, massive, or bold. Meanwhile, if referring to a minor issue or matter, the antonyms might be critical, serious, or severe.