The word 'profitless' refers to something that does not bring any financial gains or benefits. The antonyms for the word 'more profitless' include 'profitable,' 'advantageous,' 'beneficial,' 'fruitful,' 'rewarding,' 'productive,' 'useful,' 'valuable,' 'lucrative,' and 'worthwhile.' When a business venture or investment is profitable, it yields high returns for the investors or the company, and is considered worthwhile. In contrast, a profitless venture does not yield any significant financial gains and may lead to losses. Therefore, it is essential to make informed decisions based on a thorough analysis of the potential risks and benefits before investing time, effort, and money into any project or enterprise.