The phrase "most addle-brained" means extremely confused or disoriented. Some synonyms for this phrase include befuddled, befogged, muddled, bewildered, baffled, confused, flustered, and discombobulated. These words all describe a state of mind in which one is incapable of thinking clearly or making logical decisions. When someone is described as "most addle-brained," it is often because they have been overwhelmed by some situation or task, or because they are suffering from a lack of information or understanding. Regardless of the cause, it is clear that being addle-brained is not a desirable state of mind, and it is one that people generally wish to avoid.