"Most aguey" can be replaced with different synonyms depending on the context and the tone of the message. For instance, you may opt to use "most worrisome" if you want to express your concerns over a particular situation. Alternatively, you could use "most alarming" if you are talking about something that is causing a stir. "Most distressing" could also work if you want to indicate something that is causing you great sadness or discomfort. Another option could be "most frustrating" if you are annoyed with a particular scenario. "Most unsettling" and "most unnerving" are other options you could use when referring to something that is bothering you. Ultimately, it all comes down to the specific emotion you want to convey.