The word "most alchemistic" suggests a sense of mystery, magic, and transformation. However, if we were to think of its opposite or antonyms, it would mean the lack of those qualities. For example, "least alchemistic" would imply something that is straightforward, logical, and rational. It would be something that follows a set of rules and cannot be transformed through any form of magic or spell. Other antonyms of "most alchemistic" are mundane, ordinary, materialistic, unremarkable, and conventional. These words evoke the opposite of the concept of alchemy, which is about the search for the philosopher's stone, turning base metals into gold or achieving immortality.